Abstract

AbstractThe present study on β–Thalassemia major patients as regard to oxidative hypothesis to explain the influence of the free radicals and other reactive oxygen species (ROS) that accelerate the damage of cells and cause to complication of these patients. The measurement of antioxidant enzymes, Superoxide dismutase (SOD), Catalase (Cat) and glutathione reductase (GR) explanted a significantly increased for all age groups of patients compared with healthy controls. A significantly decrease of Vitamins E and A, which determined for the first time for thalassemia patients by using a Gas chromatography technique, our results proved that the patients suffer from deficiency on the levels of vitamins E and A as well as vitamin C, our study detect a significant decrease in Vitamin C (ascorbic acid) concentration at all age groups of patients as compared to healthy controls of similar age group. Study of vitamin E / vitamin C ratio ( the means ± SD are 0.7 ± 0.3, 0.84 ± 0.21, 0.88 ± 0.23, 0.85 ± 0.46 ) for age groups of patients compared with healthy controls ( 1.5 ± 0.3 and 0.99 ± 0.4). Also the correlation between SOD and Cat activity were study which can use as an index for the iron overload and oxidative stress in patients with β– Thalassemia major.

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