Abstract

Two novel Atenolol (ATN) ion selective electrodes were constructed and used for the determination of ATN in its pure form and pharmaceutical formulation. The electrodes were based on the use of the ion association complexes of either phosphomolybdic acid (PMA) or Ammonium Reineckate (AR) as anions with Atenolol cation in a PVC matrix plasticizers with tri-butyl phosphate (TBP). The results of these electrodes showed stability (life time 45 and 48 days), near Nernstian response (slope 28.8 and 31.2 mV/decade ) low detection limit (3.06×10-6 and 2.80×10-6 M ) for ATN-PMA-TBP and ATN-AR-TBP electrodes respectively. For both electrodes the best concentration for internal filling solution was 1×10-4 M ATN and the linear range was 1×10-4- 1×10-1 M and found to be usable within the pH range 9.6 – 11.0 . This study also included the measurements of selectivity of these electrodes in the presence of common cations, anions and some drug excipients. The found to be less than 1. The electrodes were successfully applied for determination of ATN both in pure form and in tablet pharmaceutical preparation with recovery of not less than 97 %.

The article was added to IASJ on 2012-11-03

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